Endocrine Abstracts

Objective: Immune checkpoint inhibitors (ICPI) have become an effective therapeutic option for certain advanced malignant tumours. Immune-related adverse events affecting thyroid function are among the most frequent toxicities. The aim of our study is to determine the prevalence of thyroid disorders in patients undergoing treatment with ICPI.Methods: Retrospective study including all patients treated with ICPI in our centre, from 07/2015 to 12/2017. Pati...

Introduction: The aim of our study was to evaluate the causes of thyrotoxicosis detected during pregnancy as well as to determine the prevalence of thyroid nodular disease (TND) in our population and which factors are associated with this condition.Methods: We performed a retrospective review of 1,760 patients between April 2014 and September 2017 remitted from the gynecology department due to thyroid dysfunction detected in the 9th week of pr...

Background: The main limitation of fine-needle aspiration (FNA) is represented by indeterminate category (Bethesda III and IV) in which the risk of malignancy is between 5-30%. Given this result, surgical treatment is necessary in many cases. The aim of our study is to assess whether the ultrasound patterns proposed by the ATA, help us to stratify the risk of malignancy in nodules with Bethesda IV cytology result.Methods: From January 2011 to June 2017 w...

Objetive: The aim of our study is to asses the validity of ultrasound patterns proposed by the ATA and malignancy risk in the cytological diagnosis classified by the Bethesda System.Methods: Prospective study including all thyroid nodules (with no previous cytological results), assessed in our center from July/2016 to June/2017. We classified nodules in ATA sonographic risk patterns and follow-up its fine needle aspiration (FNA) recommendations. The stat...

Introduction: Lingual thyroid ectopia is a rare congenital abnormality affecting embryogenesis of the gland descent from foregut through pre-tracheal region in the neck. Most cases have an asymptomatic course but may occasionally produce local obstructive symptoms. Diagnostic methods are 99mTc, 131I or 123I radionuclide scan, computed tomography scan, magnetic resonance, and ultrasound. Surgery is the elective treatment for cases presenting com...

Objectives: We studied whether the postoperative serum thyroglobulin (TG) basal levels before treatment with I131 (baseline TG) could be related with the response to treatment. We consider the excellent response as the absence of clinical, biochemical disease (undetectable TG and anti-thyroglobulin antibodies AcTG negative) and/or structural disease.Material and Methods: This is an observational study that includes 100 patients with differentiated thyroi...

Objective: The aim of this study is to evaluate clinical characteristics of patients diagnosed of follicular thyroid carcinoma and to study factors that are associated with a worse prognosis of the disease.Methods: We included 153 patients diagnosed of follicular thyroid carcinoma in our centre between January 1985 and December 2016. The baseline characteristics of the patients, and their long-term outcomes were collected. The mean follow-up was 15.2 yea...

Objective: To understand the factors associated with changes in thyroid nodule volume with previous benign citology.Material and Methods: This is a prospective single-center observational study. We included patients with a benign citology from March/2016 to May/2018 and ultrasound follow-up after 12–24 months. Initially we determined the nodule size (volume in ml), and its risk of malignancy was classified according to ATA 2015 criteria. Volume cha...

Introduction: Hypothyroidism during pregnancy has been asociated with adverse maternal and neonatal outcomes. During pregnancy, maternal levothyroxine (LT4) dose requirements increase. The aim of this study is to determine the increase of LT4 doses during pregnancy in pregestational hypothyroid women.Methods: We included 76 hypothyroid pregnant women. We analyzed analytical and clinical characteristics of these patients, as well as the increase of LT4 re...